iNuke DSP 1000


Good Morning, 

I purchased 2 x iNuke DSP and I would like to hook them up to a DIY Home Theater Speaker.  The Idea is to use the Xover on the iNuke rather then building a passive crossover. My Question is:- Is it possible to have the woofers on Channel A with a 2 Ohm Impedance then the Tweeter @ 8ohm on Channel B ? Would that cause any issues ? Or effect Sound Output?