For what it's worth...
I've set up a very simple Cubase 4.5.1 project:
145BPM, 4/4 kick played on 1 virus instance, 16th bass played on another, snare played on a Poco 01 (to use all Poco plug-ins).
If I save and load the project, the Virus instances play back with massive latency. i.e. take a long time to actually start playing when I hit play and stop when I hit stop.
Now here's the interesting bit:
If I change the buffer depth on my Hammerfall (to anything), they both fall back into sync.
If I then close that project and load it again, same thing. Huge latency for the Viri, until I change the Hammerfall's buffer size.
I'll attempt to video it and post here.
I'll also try similar on Ableton Live.
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