I only have cubase 4 but there is no problem. What standard low latency driver are you talking about? If you suspect a problem with cubase try tracktion or reaper as a test. You might have a firewire chipset problem if your computer doesn't use a firewire chipset from texas instruments (TI). Have you checked that you are using the correct firewire driver for your card? It should be using the legacy driver and nothing else.
Once again Paul... a big THANK YOU for your help. I actually thought I had tried that (storing them in order to restore after the update) but probably did something wrong. I really appreciate the power and flexibility of the X32. Its perfect for our traveling ministry, but sometimes a stretch for an old analog guy like me to wrap my head around. I'll visit the manual once again Thanks again!